Technology_

Ubichem is experienced in the field of heterocyclic chemistry especially nitrogen containing heterocycles such as quinolines, isoquinolines, pyridines, pyrimidines, pyrazines, imidazoles, indazoles, thiazoles, quinazolines, benzodiazepines. We are particularly adept at some of the more unusual ring systems, such as deazapurines, azaindole and other bicyclic and polyheterocyclic ring systems. Visit the download section to find out more.

We have a wide ranging experience in most chemical transformations and some of our key capabilities include:

• Reductions - hydride reductions (LAH, NaBH₃CN), Birch, (Fe/NH₄Cl), Na₂SO₃, TiCl₃
• Low and high pressure hydrogenation using Ni, Pd and Pt
• Grignard chemistry and organolithium chemistry
• Use of strong bases including NaH, tBuOK, LiHMDS
• Oxidations - Na/KMnO₄, CrO₃, TEMPO/bleach
• Halogenations - bromination: HBr, NBS, PBr₃ , DBDMH
• - chlorination: SOCl₂, POCl₃, Cl₂, POCl₃, NCS, DCDMH
• - cfluorination: Balz-Schiemann or electrophilic (NFSi)
• - iodination: I₂, NaI or KI exchange
• Aromatic transformations - sulfonation, chlorosulfonation, nitration, halogenation…etc
• Acetylene chemistry - use of sodium acetylide, TMSA, and acetylene gas
• Chemical and enzymatic resolutions
• Pd catalysed coupling reactions - Suzuki, Sonogashira and Heck reactions
• Thiocarbonylations [(NH₂)₂CS, KSSCOEt, chlorodimethylthiocarbamate]
• Diazotisation reactions
• Heteroaromatic ring syntheses

REAGENTS requiring special care

• Triphosgene
• Cyanation - Na/KCN
• OsO₄ - cis dihydroxylation
• Hydrazine chemistry
• Sodium azide chemistry - Curtius chemistry, amine formation
• Alkylations using MeI, dimethyl/diethyl sulphate
• Ethylene oxide
• Peroxides

Named Reactions:

Cannizaro, Diels-Alder, Knoevenagel, Mannich, Vilsmeier, Sandmeyer, Sharpless chemistry, Wolff-Kischner, Clemmensen, Rosenmund, Wadsworth-Emmons, Friedel-Crafts acylations, Buchwald-Hartwig, Henry, McMurry coupling.